CDK6/PIM1-IN-1, CAS 2677026-14-9

Product Description: CDK6/PIM1-IN-1 is a potent and balanced dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC50=3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].

Applications: Cancer-Kinase/protease

Formula: C25H28FN9

References: [1]Kai Yuan, et al. Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2022 Jan 13;65(1):857-875.

CAS Number: 2677026-14-9

Molecular Weight: 473.55

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;CDK;Pim

• SKU: MEXHY-142696-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-142696-5
• Package Unit: 5 mg
• Quantity Unit: STK