CDK8-IN-16, CAS 1860885-61-5

Product Description: CDK8-IN-16 (Compound 51) is an orally active dual inhibitor for CDK8 and CDK19 wih IC50 of 5.1 nM and 5.6 nM. CDK8-IN-16 inhibits the phospho-STAT1SER727 with an IC50 of 17.9 nM in SW620 cell, inhibits WNT signaling pathway with an IC50 of 7.2 nM in 7dF3 cell. CDK8-IN-16 exhibits good pharmacokinetic characteristics in rat models with an oral bioavailability of 57%[1].

Formula: C23H22N6O2

References: [1]Mallinger A, et al., 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. ACS Med Chem Lett. 2016 Mar 28;7(6):573-8.

CAS Number: 1860885-61-5

Molecular Weight: 414.46

Research Area: Cancer

Target: CDK;STAT;Wnt

• SKU: MEXHY-171174-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171174-0
• Package Unit: Get quote
• Quantity Unit: STK