cGAS-IN-4, CAS 2987886-49-5

Product Description: cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models[1].orally active, THP-1, C57Bl/6 mouse, orally active

Formula: C19H18Cl2N4O3

References: [1]Cyr P, et al., Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization. ACS Med Chem Lett. 2024 Nov 25;15(12):2201-2209.

CAS Number: 2987886-49-5

Molecular Weight: 421.28

Compound Purity: 99.42

Research Area: Inflammation/Immunology

Target: Cyclic GMP-AMP Synthase

• SKU: MEXHY-170362-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170362-10
• Package Unit: 10 mg
• Quantity Unit: STK