Product Description: CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C5H15ClNO2P
References: [1]William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518./[2]J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5./[3]Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275.
CAS Number: 1781834-71-6
Molecular Weight: 187.60
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: GABA Receptor
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