CHET3, CAS 2489231-47-0

Product Description: CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain[1].

Applications: Neuroscience-Neuromodulation

Formula: C21H21N5O3S

References: [1]Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

CAS Number: 2489231-47-0

Molecular Weight: 423.49

Research Area: Neurological Disease

Target: Endogenous Metabolite

• SKU: MEXHY-168166-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168166-25
• Package Unit: 25 mg
• Quantity Unit: STK