CW-2

Product Description: CW-2 is a PARP1 PROTAC degrader. CW-2 has potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and CDDP-resistant cells (A549/CDDP: IC50 = 3.52 μM). CW-2 has synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts antitumor effects by inducing DNA damage, impairing DNA repair, and activating mitochondria-dependent apoptosis (Pink: PARP1 ligand (HY-173441); Blue: E3 CRBN ligand (HY-173439); Black: linker (HY-173440))[1].

Formula: C43H42Cl2FN11O10Pt

References: [1]Li CX, et al. Pt(IV)-PROTAC Complexes with Synergistic Antitumor Activity and Enhanced Membrane Permeability. J Med Chem. 2025 Apr 24;68(8):8208-8225.

Molecular Weight: 1157.85

Research Area: Cancer

Target: DNA/RNA Synthesis;PARP;PROTACs

• SKU: MEXHY-173437-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173437-0
• Package Unit: Get quote
• Quantity Unit: STK