Cyclo(his-pro) (TFA) (Standard), CAS 936749-56-3

Product Description: Cyclo(his-pro) (TFA) (Standard) is the analytical standard of Cyclo(his-pro) (TFA). This product is intended for research and analytical applications. Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].

Formula: C13H15F3N4O4

References: [1]Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332./[2]Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35./[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.

CAS Number: 936749-56-3

Molecular Weight: 348.28

Research Area: Inflammation/Immunology; Neurological Disease

Target: Endogenous Metabolite;NF-κB;Reference Standards

• SKU: MEXHY-101402AR-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101402AR-0
• Package Unit: Get quote
• Quantity Unit: STK