D359-0396, CAS 1031977-31-7

Product Description: D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].

Applications: COVID-19-immunoregulation

Formula: C24H24N4O2

References: [1]Li Z, et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem Int. 2023 Oct;169:105565.

CAS Number: 1031977-31-7

Molecular Weight: 400.47

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: NOD-like Receptor (NLR);Pyroptosis

• SKU: MEXHY-156374-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156374-5
• Package Unit: 5 mg
• Quantity Unit: STK