DBr-1

Product Description: DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352)[1].

Applications: Cancer-programmed cell death

Formula: C55H68ClN9O5

References: [1]Schröder M, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15(1):275.

Molecular Weight: 970.64

Compound Purity: 98.87

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-156744-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156744-50
• Package Unit: 50 mg
• Quantity Unit: STK