Product Description: DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
Applications: Cancer-Kinase/protease
Formula: C9H7Br4N3
References: [1]Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37./[2]Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(/[3]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65./[4]Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42.
CAS Number: 749234-11-5
Molecular Weight: 476.79
Compound Purity: 98.41
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Casein Kinase
English
Deutsch
