DSM1465

DSM1465
SKU
MEXHY-170780-0
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Manufacturer
MedChemExpress

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Product Description: DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].

Formula: C17H12ClF6N5O2

References: [1]Nie Z, et al. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 Jan 9;68(1):590-637.

Molecular Weight: 467.75

Research Area: Infection

Target: Dihydroorotate Dehydrogenase;Parasite
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SKU MEXHY-170780-0
Manufacturer MedChemExpress
Manufacturer SKU HY-170780-0
Package Unit Get quote
Quantity Unit STK
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