E0924G, CAS 2909474-29-7

Product Description: E0924G is an orally active activator for PPARδ with EC50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models[1].

Formula: C12H12N2O3

References: [1]Li Y, et al., The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice. Bioorg Chem. 2024 Jun;147:107364.

CAS Number: 2909474-29-7

Molecular Weight: 232.24

Compound Purity: 99.17

Research Area: Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: PPAR

• SKU: MEXHY-168336-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168336-50
• Package Unit: 50 mg
• Quantity Unit: STK