E197, CAS 2378515-04-7

Product Description: E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models[1].

Formula: C19H21ClN2O3S

References: [1]Mounier L, et al., Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem. 2020 Nov 25;63(22):13680-13694.

CAS Number: 2378515-04-7

Molecular Weight: 392.90

Research Area: Metabolic Disease

Target: DOCK

• SKU: MEXHY-164587-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164587-0
• Package Unit: Get quote
• Quantity Unit: STK