EB-TCIP

Product Description: EB-TCIP (BAK-04-212) is a bivalent molecule comprised of AP1867 (HY-114434) and BI-3812 (HY-111381). EB-TCIP can form a reversible ternary complex between FKBPF36V and BCL6BTB. EB-TCIP recruits FKBP12F36V-tagged EWS/FLI1 to DNA sites bound by the transcriptional regulator BCL6, leading to rapid expression of BCL6 target genes (eg: SOCS2 and CXCL11). EWS/FLI1 is a fusion transcription factors in Ewing sarcoma. EB-TCIP can be used for research of deregulated transcription in cancer[1].

Formula: C68H86ClN9O15

References: [1]Bond MJ, et al. Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643353.

Molecular Weight: 1304.91

Research Area: Cancer

Target: BCL6

• SKU: MEXHY-173364-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173364-0
• Package Unit: Get quote
• Quantity Unit: STK