eIF4A3-IN-12, CAS 1402931-76-3

Product Description: eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].

Applications: Cancer-programmed cell death

Formula: C27H25ClO7

References: [1]Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

CAS Number: 1402931-76-3

Molecular Weight: 496.94

Compound Purity: 99.70

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Eukaryotic Initiation Factor (eIF)

• SKU: MEXHY-148446-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-148446-0
• Package Unit: Get quote
• Quantity Unit: STK