Product Description: Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.IC50：In Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, 30 μM, respectively[1]. In Vivo:
Applications: Cancer-programmed cell death
Formula: C17H10F6N6O
References: [1]Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25./[2]Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21./[3]Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24.
CAS Number: 1642300-78-4
Molecular Weight: 428.29
Compound Purity: 95.98
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: CRM1
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