Enpp-1-IN-25, CAS 3067908-20-4

Enpp-1-IN-25, CAS 3067908-20-4
SKU
MEXHY-168491-0
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MedChemExpress

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Product Description: Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy[1].

Formula: C15H21N5O4S

References: [1]He J, et al. Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy. J Med Chem. 2025 Feb 20.

CAS Number: 3067908-20-4

Molecular Weight: 367.42

Research Area: Cancer

Target: PD-1/PD-L1;Phosphodiesterase (PDE);STING
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SKU MEXHY-168491-0
Manufacturer MedChemExpress
Manufacturer SKU HY-168491-0
Package Unit Get quote
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