Product Description: EU 1622-240 is a biased positive allosteric modulator of GluN2B, GluN2C, and GluN2D, with EC50s of 0.57, 0.82, 1.1 μM respectively. EU 1622-240 has good physicochemical properties, in vitro stability, and permeability[1].
Formula: C20H14BrF2N3O2S
References: [1]Fritzemeier RG, et al. Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl-d-Aspartate Receptor. J Med Chem. 2025 May 8;68(9):9303-9322.
CAS Number: 3057728-22-7
Molecular Weight: 478.31
Research Area: Neurological Disease
Target: iGluR