EXQ-2d

Product Description: EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86). EXQ-2d inhibits WNT/β-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 μM and 77 μM[1].

Applications: Cancer-programmed cell death

Formula: C18H17N3O3

References: [1]Bosetti C, et al., Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur J Med Chem. 2025 Feb 15;288:117397.

Molecular Weight: 323.35

Research Area: Cancer

Target: PARP;Wnt;β-catenin

• SKU: MEXHY-168925-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168925-0
• Package Unit: Get quote
• Quantity Unit: STK