Product Description: FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282)-induced colitis in mouse model[1][2].
Applications: COVID-19-immunoregulation
Formula: C23H18N2O3S
References: [1]Dvořák Z, et al., In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6. Bioorg Chem. 2024 Mar;144:107137./[2]Dvořák Z, et al., Targeting the pregnane X receptor using microbial metabolite mimicry. EMBO Mol Med. 2020 Apr 7;12(4):e11621.
CAS Number: 2238839-34-2
Molecular Weight: 402.47
Compound Purity: 99.14
Research Area: Inflammation/Immunology
Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Interleukin Related;NF-κB
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