Product Description: FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP shows antiproliferative activity against breast cancer[1].
Formula: C18H18Cl2N2O7Pt
References: [1]Cai L, et al. Platinum(IV) Complexes Trigger Death Receptors and Natural Killer Cells to Suppress Breast Cancer. J Med Chem. 2025 Jan 31.
Molecular Weight: 640.33
Research Area: Cancer
Target: Apoptosis;Bcl-2 Family;Caspase;MDM-2/p53;PARP;Reactive Oxygen Species