FXR agonist 12, CAS 1831862-88-4

Product Description: FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models[1].

Formula: C26H44O3

References: [1]Yang J, et al., Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell. 2024 Dec 12;187(25):7164-7182.e18.

CAS Number: 1831862-88-4

Molecular Weight: 404.63

Research Area: Inflammation/Immunology

Target: FXR

• SKU: MEXHY-164799-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164799-0
• Package Unit: Get quote
• Quantity Unit: STK