Product Description: G-6599 is a SMARCA2/A4 target-anchored monovalent degrader with DC50 values of 0.018 nM and 0.056 nM, respectively. G-6599 has degradation activity and anti-proliferative effects in AR-dependent prostate cancer cell lines[1].
Formula: C31H37N7O
References: [1]Elisia Villemure, et al. Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22. bioRxiv. 2025, 3, 7.
CAS Number: 2901806-51-5
Molecular Weight: 523.67
Research Area: Cancer
Target: Epigenetic Reader Domain