Product Description: Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].
Applications: COVID-19-immunoregulation
Formula: C22H24ClF2N5O
References: [1]Kuhen KL, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother. 2014;58(9):5060-5067./[2]Leong FJ, et al. A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers. Antimicrob Agents Chemother. 2014;58(11):6437-6443.
CAS Number: 2751586-94-2
Molecular Weight: 447.91
Compound Purity: 98.0
Research Area: Infection
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 33.33 mg/mL (ultrasonic)
Target: Parasite
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