GAPDH-IN-1, CAS 252212-58-1

Product Description: GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C20H18N2O5

References: [1]Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17(2):340-347.

CAS Number: 252212-58-1

Molecular Weight: 366.37

Research Area: Metabolic Disease

Target: Endogenous Metabolite

• SKU: MEXHY-171036-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171036-5
• Package Unit: 5 mg
• Quantity Unit: STK