Gardiquimod (diTFA) (Standard), CAS 1159840-61-5

Product Description: Gardiquimod (diTFA) (Standard) is the analytical standard of Gardiquimod (diTFA). This product is intended for research and analytical applications. Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM.

Formula: C21H25F6N5O5

References: [1]Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18./[2]Ma F, et al. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell Mol Immunol. 2010 Sep;7(5):381-8./[3]Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306.

CAS Number: 1159840-61-5

Molecular Weight: 541.44

Research Area: cancer

Target: Reference Standards;Toll-like Receptor (TLR)

• SKU: MEXHY-103697AR-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103697AR-0
• Package Unit: Get quote
• Quantity Unit: STK