GDC-2992, CAS 2753651-10-2

Product Description: GDC-2992 (Compound 28A) is an orally active androgen receptor (AR) degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. (Structure Note: Pink: target protein ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189A); Black: linker (HY-169975); E3 ligase ligand +linker (HY-169976A))[1].

Applications: Cancer-programmed cell death

Formula: C45H51ClN8O5

References: [1]HF Lu, et al. 酞嗪酮类化合物及其制备方法和医药用途. WO2021249534A1.

CAS Number: 2753651-10-2

Molecular Weight: 819.39

Research Area: Cancer

Target: Androgen Receptor;PROTACs

• SKU: MEXHY-156751A-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156751A-100
• Package Unit: 100 mg
• Quantity Unit: STK