Glucocerebrosidase-IN-2, CAS 851185-20-1

Product Description: Glucocerebrosidase-IN-2 (compound 12) is a quinazoline analogue and an inhibitor of glucocerebrosidase (GC). Glucocerebrosidase-IN-2 has the potential to improve GC translocation to lysosomes in Gaucher disease patient-derived cells (mostly carrying the N370S mutation). Glucocerebrosidase-IN-2 inhibits the hydrolysis of 4-methylumbelliferone β-D-glucopyranoside (4MU) and fluorescent glycosylceramide (FlourGC) in N370S mutant tissues with an AC50 of 25.29 μM[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C25H23N5O4S

References: [1]Juan J Marugan, et al. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. J Med Chem. 2011, 54, 4.

CAS Number: 851185-20-1

Molecular Weight: 489.55

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Glycosidase

• SKU: MEXHY-156020-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156020-10
• Package Unit: 10 mg
• Quantity Unit: STK