Glucosylceramide synthase-IN-3, CAS 3029827-91-3

Product Description: Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C21H20FN3O3

References: [1]Mali Cosden, et al. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiol Dis. 2021 Nov;159:105507./[2]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290

CAS Number: 3029827-91-3

Molecular Weight: 381.40

Research Area: Metabolic Disease; Neurological Disease

Solubility: 10 mM in DMSO

Target: Glucosylceramide Synthase (GCS)

• SKU: MEXHY-144270-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-144270-50
• Package Unit: 50 mg
• Quantity Unit: STK