GSK-3 inhibitor 4, CAS 2227279-83-4

Product Description: GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].

Applications: Neuroscience-Neurodegeneration

Formula: C22H15F2N5O

References: [1]Hartz RA, et al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.

CAS Number: 2227279-83-4

Molecular Weight: 403.38

Compound Purity: 98.77

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: CDK;GSK-3

• SKU: MEXHY-154852-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-154852-1
• Package Unit: 1 mg
• Quantity Unit: STK