GSK-3β inhibitor 24, CAS 3069913-37-4

Product Description: GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects[1].

Applications: Neuroscience-Neurodegeneration

Formula: C26H18N4O3

References: [1]Xun QQ, et al. Synthesis and biological evaluation of novel pyrrolo[2,3-b]pyridine derivatives as potent GSK-3β inhibitors for treating Alzheimer's disease. Eur J Med Chem. 2025 Jan 2;285:117236.

CAS Number: 3069913-37-4

Molecular Weight: 434.45

Research Area: Neurological Disease

Target: GSK-3;Tau Protein;β-catenin

• SKU: MEXHY-168857-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168857-0
• Package Unit: Get quote
• Quantity Unit: STK