H052, CAS 2886748-00-9

Product Description: H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus[1].

Formula: C21H15ClFN3O4S

References: [1]Shekhar A, et al. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host Microbe. 2025 Apr 9;33(4):560-572.e21.

CAS Number: 2886748-00-9

Molecular Weight: 459.88

Research Area: Infection

Target: Bacterial;Calcium Channel

• SKU: MEXHY-173526-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173526-0
• Package Unit: Get quote
• Quantity Unit: STK