HDAC-IN-27 (dihydrochloride), CAS 3069831-25-7

Product Description: HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 dihydrochloride exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia (AML)[1].

Applications: Cancer-programmed cell death

Formula: C20H24Cl2N4O2

References: [1]Jiang Y, et al. Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo. J Med Chem. 2022;65(1):285-302.

CAS Number: 3069831-25-7

Molecular Weight: 423.34

Research Area: Cancer

Target: Apoptosis;HDAC

• SKU: MEXHY-142690A-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-142690A-10
• Package Unit: 10 mg
• Quantity Unit: STK