HDAC11-IN-2, CAS 2919766-97-3

Product Description: HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 ×10-3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C25H35N3O3

CAS Number: 2919766-97-3

Molecular Weight: 425.56

Compound Purity: 99.52

Research Area: Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: AMPK;HDAC

• SKU: MEXHY-172157-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172157-25
• Package Unit: 25 mg
• Quantity Unit: STK