HDAC3-IN-6

Product Description: HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1. HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS. HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer[1].

Formula: C23H23N5O3

References: [1]Sun Z, et al. Discovery of Novel Hydrazide-Based HDAC3 Inhibitors as Epigenetic Immunomodulators for Cancer Immunotherapy. J Med Chem. 2025 Feb 13;68(3):3048-3064.

Molecular Weight: 417.46

Research Area: Cancer; Inflammation/Immunology

Target: Apoptosis;HDAC;PD-1/PD-L1;Reactive Oxygen Species

• SKU: MEXHY-172133-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172133-0
• Package Unit: Get quote
• Quantity Unit: STK