Product Description: HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM and 7374.5 nM for HDAC6 and HDAC1, respectively. HDAC6-IN-58 increases tubulin acetylation, exerts antiproliferative effects, and induces autophagy[1].
Formula: C28H28F2N4O3
References: [1]Barone S, et al. Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies. Eur J Med Chem. 2025 Apr 18;292:117634.
Molecular Weight: 506.54
Research Area: Cancer
Target: Autophagy;HDAC