Heme Oxygenase-1-IN-1 (hydrochloride), CAS 1092851-70-1

Heme Oxygenase-1-IN-1 (hydrochloride), CAS 1092851-70-1
SKU
MEXHY-111798A-25
Packaging Unit
25 mg
Manufacturer
MedChemExpress

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Product Description: Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM[1].

Applications: Cancer-programmed cell death

Formula: C13H16BrClN2

Citations: Cell Death Dis. 2022 Sep 26;13(9):822./Free Radic Biol Med. 2023 Mar 27;202:46-61./Front Oncol. 2021 May 26;11:679816./Front Oncol. 24 September 2021./Nitric Oxide. 8 October 2022./J Clin Invest. 2024 Dec 2;134(23):e181044./Mar Drugs. 2025 Mar 12;23(3):123.

References: [1]Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339./[2]Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. /[3]Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132.

CAS Number: 1092851-70-1

Molecular Weight: 315.64

Compound Purity: 99.03

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)

Target: Reactive Oxygen Species
More Information
SKU MEXHY-111798A-25
Manufacturer MedChemExpress
Manufacturer SKU HY-111798A-25
Package Unit 25 mg
Quantity Unit STK
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