HEMTAC WEE1 degrader-1, CAS 3002417-64-0

Product Description: HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC50: 16.76 nM). HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker)[1].

Formula: C57H71N15O6

References: [1]Li X, et al. Design, synthesis and biological evaluation of WEE1 degraders via HSP90-mediated targeting chimeras for target therapy of acute myeloid leukemia. Eur J Med Chem. 2025 Jun 5;290:117512.

CAS Number: 3002417-64-0

Molecular Weight: 1062.27

Research Area: Cancer

Target: HSP;Wee1

• SKU: MEXHY-173320-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173320-0
• Package Unit: Get quote
• Quantity Unit: STK