HGC652, CAS 3055558-98-7

Product Description: HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1].

Formula: C23H28FNO3S2

References: [1]Li X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21[J]. bioRxiv, 2024: 2024.12. 03.626577.

CAS Number: 3055558-98-7

Molecular Weight: 449.60

Research Area: Cancer

Target: E1/E2/E3 Enzyme;Molecular Glues

• SKU: MEXHY-170430-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170430-10
• Package Unit: 10 mg
• Quantity Unit: STK