Product Description: Hispidin (Standard) is the analytical standard of Hispidin. This product is intended for research and analytical applications. Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1][2][3][4][5][6][7].
Formula: C13H10O5
References: [1]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327(2):264-75./[2]Wu F, et al. Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells. Evid Based Complement Alternat Med. 2023 Feb 21;2023:9428241./[3]Han Y H, et al. Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways[J]. Applied Biological Chemistry, 2020, 63: 1-9./[4]Lai MC, et al. Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson's Disease. Nutrients. 2023 Jan 20;15(3):549./[5]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327(2):264-75./[6]Huang SY, et al. The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. Biomolecules. 2019 Aug 19;9(8):380./[7]Liu YS, et al. Exploring the Wound Healing Potential of Hispidin. Nutrients. 2024 Sep 19;16(18):3161.
CAS Number: 555-55-5
Molecular Weight: 246.22
Research Area: Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Target: Akt;Endogenous Metabolite;ERK;Ferroptosis;GSK-3;JAK;JNK;Keap1-Nrf2;p38 MAPK;PKC;Reactive Oxygen Species;Reference Standards;STAT
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