HTT-D3, CAS 2254502-89-9

Product Description: HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1].

Applications: Neuroscience-Neurodegeneration

Formula: C23H25FN6

References: [1]Anuradha Bhattacharyya, et al. Small molecule splicing modifiers with systemic HTT-lowering activity. Nat Commun. 2021 Dec 15;12(1):7299.

CAS Number: 2254502-89-9

Molecular Weight: 404.48

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: P-glycoprotein

• SKU: MEXHY-143792-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-143792-5
• Package Unit: 5 mg
• Quantity Unit: STK