Product Description: Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection[1][2][3][4][5][6].
Formula: N/A
Citations: Cell Biosci. 2023 Aug 10;13(1):147./Cell Oncol (Dordr). 2024 Dec 24./Drug Dev Ind Pharm. 2023 Mar 27;1-37./Mol Cancer. 2024 Jan 10;23(1):12./Nat Commun. 2023 May 26;14(1):3050./Theranostics. 2023; 13(6):2040-2056./Cell Death Dis. 2025 Mar 20;16(1):190.
References: [1]Vartanian AJ, et al. Injected hyaluronidase reduces restylane-mediated cutaneous augmentation. Arch Facial Plast Surg. 2005 Jul-Aug;7(4):231-7./[2]Brandon E, et al. The Use of Hyaluronidase in Cosmetic Dermatology: A Review of the Literature. J Clin Investigat Dermatol. 2015;3(2): 7./[3]Apaza Ticona L, et al. Rubus urticifolius Compounds with Antioxidant Activity, and Inhibition Potential against Tyrosinase, Melanin, Hyaluronidase, Elastase, and Collagenase[J]. Pharmaceuticals (Basel). 2024 Jul 13;17(7):937./[4]Jung H. Hyaluronidase: An overview of its properties, applications, and side effects[J]. Arch Plast Surg. 2020 Jul;47(4):297-300./[5]Lee W, et al. Comparative Effectiveness of Different Interventions of Perivascular Hyaluronidase[J]. Plast Reconstr Surg. 2020 Apr;145(4):957-964./[6]Wang M, et al. Comparison of Intra-arterial and Subcutaneous Testicular Hyaluronidase Injection Treatments and the Vascular Complications of Hyaluronic Acid Filler[J]. Dermatol Surg. 2017 Feb;43(2):246-254./[7] Kim DW, et al. Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management. J Plast Reconstr Aesthet Surg. 2011 Dec;64(12):1590-5. /[8]Gong H, et al. Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy. Nano Lett. 2016 Apr 13;16(4):2512-21.
CAS Number: 37326-33-3
Molecular Weight: 55000 (average)
Research Area: Inflammation/Immunology; Cancer
Solubility: H2O : 100 mg/mL (ultrasonic)
Target: NF-κB
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