I2-IRs ligand-1

Product Description: I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I2 receptors (I2-IRs) (pKi: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders[1].

Applications: COVID-19-immunoregulation

Formula: C21H23ClFN2O4P

References: [1]Bagán A, et al. Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties. J Med Chem. 2025 Feb 13;68(3):2551-2573.

Molecular Weight: 452.84

Research Area: Inflammation/Immunology; Neurological Disease

Target: Imidazoline Receptor

• SKU: MEXHY-170994-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170994-0
• Package Unit: Get quote
• Quantity Unit: STK