Product Description: ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3[1].
Applications: Cancer-programmed cell death
Formula: C29H27F3N8O3S
References: [1]Jeong Eun Kim, et al. Abstract 5601: ID11916, a novel androgen receptor antagonist with cGMP-dependent protein kinase activation for next-generation therapeutics in AR positive tumors. Cancer Res (2025) 85 (8_Supplement_1): 5601.
CAS Number: 2785317-21-5
Molecular Weight: 624.64
Research Area: Cancer
Target: Androgen Receptor;Phosphodiesterase (PDE)
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