IDH2R140Q-IN-2, CAS 2749568-16-7

Product Description: IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML)[1].

Applications: Cancer-programmed cell death

Formula: C21H18F6N6O

References: [1]Wei Q, et al. Structure-Based Drug Design of Novel Triaminotriazine Derivatives as Orally Bioavailable IDH2R140Q Inhibitors with High Selectivity and Reduced hERG Inhibitory Activity for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2023 Sep 28;66(18):12894-12910.

CAS Number: 2749568-16-7

Molecular Weight: 484.40

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Isocitrate Dehydrogenase (IDH)

• SKU: MEXHY-156158-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156158-1
• Package Unit: 1 mg
• Quantity Unit: STK