INF 195, CAS 1211379-56-4

Product Description: INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].

Applications: COVID-19-immunoregulation

Formula: C17H22ClNO3

References: [1]Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397.

CAS Number: 1211379-56-4

Molecular Weight: 323.81

Compound Purity: 99.58

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: Interleukin Related;NOD-like Receptor (NLR);Pyroptosis

• SKU: MEXHY-164304-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164304-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK