Insecticidal agent 19

Product Description: Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM[1].

Formula: C26H15ClN4O6

References: [1]Batran RZ, et al., Synthesis and mechanistic insights of Coumarinyl-Indolinone hybrids as potent inhibitors of Leishmania major. Eur J Med Chem. 2025 Feb 12;288:117392.

Molecular Weight: 514.87

Research Area: Infection

Target: Dihydrofolate reductase (DHFR) ;Parasite

• SKU: MEXHY-168918-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168918-0
• Package Unit: Get quote
• Quantity Unit: STK