Product Description: Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
Applications: COVID-19-immunoregulation
Formula: C21H33ClN2O3
Citations: Biochem Pharmacol. 2020 Oct;180:114122./Biochem Pharmacol. 2023 Mar 24;211:115516./Front Pharmacol. 2020 Dec 14./J Am Heart Assoc. 2021 Jul 3;e018833./Pnas nexus . 2023 Dec 22.
References: [1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8./[2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na(+),K(+)-ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch/[3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744). J Pharmacol Exp Ther. 2002 Nov;303(2):592-600.
CAS Number: 374559-48-5
Molecular Weight: 396.95132
Compound Purity: 99.32
Research Area: Cardiovascular Disease
Solubility: DMSO : ≥ 45 mg/mL/H2O : 25 mg/mL (ultrasonic)
Target: Calcium Channel;Na+/K+ ATPase
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