JH-II-127, CAS 1700693-08-8

Product Description: JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome[1].

Applications: Neuroscience-Neuromodulation

Formula: C19H21ClN6O3

References: [1]Hatcher JM, et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9.

CAS Number: 1700693-08-8

Molecular Weight: 416.86

Compound Purity: 98.0

Research Area: Neurological Disease

Solubility: DMSO : 110 mg/mL (ultrasonic)

Target: LRRK2

• SKU: MEXHY-16936-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16936-25
• Package Unit: 25 mg
• Quantity Unit: STK