Product Description: JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity[1].
Applications: Cancer-Kinase/protease
Formula: C19H17FN4O3
References: [1]Shaalan M M, et al. Novel 3, 6-Disubstituted Pyridazine Derivatives Targeting JNK1 Pathway: Scaffold Hopping and Hybridization-Based Design, Synthesis, Molecular Modeling, and In Vitro and In Vivo Anticancer Evaluation[J]. ACS Omega, 2024.
CAS Number: 3056388-71-4
Molecular Weight: 368.36
Compound Purity: 98.44
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target: JNK
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